ALZ DISCOVERY

S-nitrosylation is the covalent addition of a nitric oxide (NO) group to a cysteine thiol group (-SH) to form S-nitrosothiols (SNO)

https://en.wikipedia.org/wiki/S-Nitrosylation

In Alz inflammation: overactivity occurs:

STING is normally part of the body’s early warning system. It helps detect threats, such as viruses, and activates the immune response. In a healthy situation, this is very helpful. But in Alzheimer’s disease, the researchers found that STING becomes overactive.

reason for this overactivity is a chemical change called S-nitrosylation. This is a process where a small molecule related to nitric oxide attaches to a protein and changes how it works

https://knowridge.com/2026/04/study-finds-big-cause-of-brain-inflammation-in-alzheimers-disease/