Alzheimer’s breakthrough?

Read "Alzheimer’s breakthrough? Scientists use nanotech to reverse disease in mice" on SmartNews: https://l.smartnews.com/p-6lkwYsuY/Dc7ISq

new study reveals innovative nanotechnology that restored the function of the blood-brain barrier (BBB) to reverse Alzheimer’s in mice.

They’re called “supramolecular drugs.”

Here’s how they work: The BBB plays a crucial role in regulating the brain’s environment by defending it against pathogens, toxins and other dangers.

Alzheimer’s is characterized by an accumulation of “waste proteins,” most notably amyloid-beta, which compromises normal neural function.

The team administered three doses of the supramolecular drugs to mice with high quantities of amyloid-beta in their brain.

“Only one hour after the injection, we observed a reduction of 50-60% in [amyloid-beta] amount inside the brain,” said Junyang Chen, first co-author of the study and a researcher at the West China Hospital of Sichuan University.

Researchers studied the mice over several months, conducting experiments, monitoring their memory decline and assessing the therapeutic effects of the supramolecular drugs.

In one such trial, a 12-month-old mouse, which is the equivalent of a 60-year-old human, was treated with nanoparticles and observed for six months.