Bats don't get cancer. but live 180yrs in human yrs

 University of Rochester team set out to uncover why, zeroing in on four bat species spanning both major bat lineages.

Their findings point to a finely tuned partnership between an overachieving tumor suppressor gene, self-renewing chromosomes, and an immune system that fights hard but rarely overreacts.

The work was led by Vera Gorbunova and Andrei Seluanov of the Wilmot Cancer Institute and Department of Biology.

Bats defy aging and cancer patterns

Cancer risk usually rises with age because every round of cell division adds another chance for DNA damage, a pattern known as Peto's paradox

Across most mammals the equation holds, but bats are clear outliers, with at least four separate bat lineages independently evolving extreme longevity.

The new study shows that the "little brown" bat (Myotis lucifugus) carries two working copies of the key tumor suppressor gene p53, while humans carry only one.

"High levels of p53 in the body can kill cancer cells before they become harmful in a process known as apoptosis," said Gorbunova.

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